The claim

““Vitamin B6 (pyridoxine) supplements can cause nerve damage (peripheral neuropathy), even at doses people think are ‘safe.’””

High-dose vitamin B6 is a well-documented cause of peripheral neuropathy, and some cases have been reported at relatively modest doses, though typical dietary intake is not the concern.

Medical regulators and clinical references recognize pyridoxine toxicity as a cause of sensory neuropathy, most often with chronic high supplemental doses rather than food sources. The NIH notes neuropathy has been reported with long-term intakes above about 100 mg/day and that symptoms generally resolve after stopping, though recovery can be slow or incomplete in some cases. The European Food Safety Authority (EFSA) recently reassessed the risk and set a lower tolerable upper intake level for adults (12 mg/day), reflecting evidence that neuropathy can occur at lower supplemental intakes than previously assumed, but this does not mean everyone will be harmed at that level. Overall, the claim is directionally correct (B6 supplements can cause nerve damage), but the risk depends strongly on dose, duration, individual susceptibility, and supplement labeling accuracy.